Na procura de um caminho personalizado

Tal como acontece com as pessoas, cada tumor é único. O nosso leque de serviços de perfil genómico abrangente, oferece informações importantes que podem contribuir para otimizar e personalizar estratégias de tratamento para doentes em diversas situações clínicas.1–6

Perfil genómico abrangente

O perfil genómico abrangente da Foundation Medicine analisa toda a região codificante dos genes frequentemente alterados no cancro e, potencialmente, amplia as opções de tratamento do doente.*1–5

Concluída a análise, o médico recebe um relatório detalhado e de fácil leitura, que fornece informações relevantes sobre o perfil genómico do tumor do doente, possíveis terapêuticas dirigidas ou imunoterapias aplicáveis, bem como de eventuais ensaios clínicos em curso, para apoiar a tomada de decisão clínica.7

Uma abordagem ao perfil genómico abrangente
Um leque de serviços de elevada qualidade

Serviços Foundation Medicine

Os serviços Foundation Medicine possibilitam otimizar e personalizar as estratégias de tratamento para doentes em diversas situações clínicas.1,8–9

Os nossos serviços

Fornece informação relativa ao diagnóstico, prognóstico e fatores preditivos, para fundamentar o tratamento Aumenta as hipóteses de realizar o perfil genómico abrangente do tumor com uma única amostra de sangue Orienta decisões de tratamento eficientes e personalizados FFPE, sangue periférico, aspirado da medula óssea Quando não é possível obter uma amostra de tecido tumoral, quando este é insuficiente para proceder à análise ou ainda quando há suspeita de progressão da doença, analisa-se DNA proveniente de sangue periférico. Analisa DNA proveniente de uma amostra de tecido tumoral (biópsia). Dependendo do tipo de tumor, o DNA e o RNA a ser testados poderão ser provenientes de uma amostra de sangue periférico ou de uma amostrasólida de tecido tumoral. Visão geral FFPE Sangue periférico Tipo de amostra >300 ~70 >400 (>250 RNA) Genes EXPLORAR EXPLORAR EXPLORAR Carga mutacional do tumor (TMB) Instabilidade de microssatélites (MSI) TESTES PARA TUMORES SÓLIDOS 1 TESTES PARA TUMORES HEMATOLÓGICOS e SARCOMAS 9 TESTES EM BIÓPSIA LÍQUIDA 8 eJzkvdeW8sjSKDjXe616ByiHB0l4WxgJXwVFUd5QGGEKI0qC3vv7L+Zl5mLWPMA8wf9ik5nyQg7T Z/qc03t3NaDIjMzIyHAZobxyth8ChREzoAPhIOY4+9fVVYml+xuGTTnQz47aYrHlNiz8yd3xOPB4 EINQhVqiJ0A+0Sw3Y1YpB0EEcf5pGbZ33/bH/cWo77gFUJzH4fbAR93ZZkGDhxjRmzJLet2f0D0s 0mP+otm/ZvS/HczYwcGPQ5rr/UUEMBz8P8j9NfFIYwO4yP4G9BEL4fEQgeFJRzwVxh3tWwTSX/3V 57jZfwEAPBZOhOGPRWa7Gs1WkyLzn5QDA//DiVjYkYyih9VZh+ZMIUhmuF3Sq02bZcCwuBKzYFgu 5Sj96a/A5CbgSd/xSi8WzL8dxUV/OFe2KTOrDYCtMJtpfxkoMosRfOqTf2BU4Hc0PaJH9hoVatFe ebagAbWX/Y0DDyPiF2o40StuZ4vR3XY5oMFChHEC/R7uoZE/cmDIYPTwM/o93qstwU8P9GYDKADw ojXsVIrK+fJUwRzu9w49mSGOAAvx6RF7Zpn1ss/OOZF6eFSgHnzapZfrBVgzRN0YFgtGHZF4FPxV fBZBwYQQGIFFwCM8GXckE3HwKR6NCSDyctCQZVKOO2ZFC/QosJsHfu0jEQzj/wqPOtsFzT6uZpCy 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Compromisso conjunto

No contexto do compromisso a longo prazo com a inovação na área da medicina personalizada, a Roche e a Foundation Medicine pretendem facilitar o acesso ao perfil genómico abrangente a todos os doentes oncológicos. 10
Roche Foundation Medicine

 

 

 

*O perfil genómico abrangente permite a análise de DNA do tumor recorrendo à tecnologia de sequenciação de nova geração (NGS) para identificar as quatro classes de alterações genómicas num conjunto alargado de genes relacionados com o cancro. O perfil genómico abrangente é uma abordagem aplicável a qualquer tipo de cancro.

DNA (Deoxyribonucleic acid) = ADN (Ácido desoxirribonucleico) | FFPE = fixado em formol e incluído em parafina | MSI = Instabilidade de microssatélites | RNA (Ribonucleic acid) = ARN (Ácido ribonucleico) | TMB = Carga mutacional do tumor

Referências
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  2. Drilon A et al. Clin Cancer Res 2015; 21: 3631–3639.
  3. Rankin A et al. Oncologist 2016; 21: 1306–1314.
  4. Ross JS et al. Cancer 2016; 122: 2654–2662.
  5. Suh JH et al. Oncologist 2016; 21: 684–691.
  6. Hirshfield KM et al. Oncologist 2016; 21: 1315–1325.
  7. Foundation Medicine: A Patient’s Guide to Comprehensive Genomic Profiling, 2019. Available at: go.roche.com/foundationmedicinepatientbooklet (Accessed July 2019).
  8. Clark TA et al. J Mol Diagn 2018; 20: 686–702.
  9. He J et al. Blood 2016; 127: 3004–3014.
  10. Roche Media Release, 2018. Available at: https://www.roche.com/media/releases/med-cor-2018-06-19.htm (Accessed July 2019).